Abstract
Glass microelectrode recording method was used to investigate the effect of injection of thyrotropin-releasing hormone (TRH) into nucleus accumbens, nucleus amygdalae or nucleus caudatus on unit discharges from pain-excitation neurons (PEN) in nucleus parafascicularis of the thalamus in rats. The results showed that: 1) Injection of TRH into the nucleus accumbens resulted in a significant inhibition of pain discharges from PEN in nucleus parafascicularis, while injection of TRH into nucleus amygdalae, nucleus caudatus exerted no significant effect. 2) Pretreatment with atropine abolished the above-mentioned effect of TRH. 3) Pretreatment with haloperidol also abolished the above-mentioned inhibitory effect of TRH. 4) Pretreatment with naloxone, propranolol or phentolamine did not affect the inhibitory effect of TRH. These results suggested that nucleus accumbens might be a special area in response to TRH and the effect of TRH seems to be involved in both cholinergic M-receptor and dopaminergic receptor.
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