Abstract
This paper reports the effect of tosyl-phenylalanyl-chloromethyl ketone, Pepstatin, Antipain, Leupeptin and Trasylol, all inhibitors of proteolytic enzymes, on the growth and morphology of normal and polyoma transformed baby hamster kidney cells in culture. Above 1 μM, tosyl phenylalanyl chloromethyl ketone inhibited the growth of both normal and transformed cells to the same extent, and also inhibited the incorporation of radioactive leucine into protein. Pepstatin and Antipain also had no differential effect on the growth of normal or transformed cells, while Leupeptin and Trasylol inhibited the growth of normal cells more than transformed cells.
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