Abstract
BACKGROUND: One of the most promising markers of allergic inflammation is eotaxin, which has a selective influence on the migration of eosinophils. Its serum content significantly correlates with the intensity of allergic symptoms, so it might be interesting to know whether vaccination has any influence on serum expression of this chemokine. AIMS: Comparison of the humoral response to influenza vaccine and post-vaccination changes in the serum eotaxin level in patients with allergic bronchial asthma and healthy controls. METHODS: Forty-two asthmatics and 45 healthy individuals were vaccinated with a single dose of influenza subunit vaccine (Influvac). The serum eotaxin level and the antibody response to haemagglutinin (HI) and neuraminidase (NI) glycoproteins were measured before and after vaccination. RESULTS: A significant increase of geometric mean titres of HI and NI was observed in both groups. There were no significant differences between the groups in meanfold increase of HI and NI titres, response rate and protective level of HI. After vaccination, a significant decrease of the mean serum eotaxin value was observed in patients with asthma (149.4 +/- 71.0 versus 125.1 +/- 67.0, p= 0.0017), while no similar effect was present in healthy individuals (153.4 +/- 56.9 versus 159.3 +/- 54.4, p= 0.5). CONCLUSIONS: The results indicate that in patients with allergic bronchial asthma influenza vaccinations assure efficient protective antibody level and modulate the serum level of eotaxin.
Highlights
Influenza is one of the most common respiratory tract diseases
One of the most promising markers of allergic inflammation is eotaxin, which has a selective influence on migration of eosinophils.[7]
There was a significant increase of the geometric mean titres (GMT) of HI and NI antibodies to the three virus antigens in both studied groups (Wilcoxon’s rank-sum test, p B/0.05)
Summary
Influenza is one of the most common respiratory tract diseases. Infections with influenza virus can cause exacerbations of bronchial asthma and, in consequence, can lead to life-quality impairment and higher mortality in patients with asthma.[1]. One of the most promising markers of allergic inflammation is eotaxin, which has a selective influence on migration of eosinophils.[7] Á9 Many authors have revealed that the concentration of eotaxin is higher in patients with allergic bronchial asthma.[10,11] In this study we assess humoral antibody response and changes in serum eotaxin level after influenza vaccinations in healthy people and inpatients with allergic bronchial asthma. Aims : Comparison of the humoral response to influenza vaccine and post-vaccination changes in the serum eotaxin level in patients with allergic bronchial asthma and healthy controls. Conclusions : The results indicate that in patients with allergic bronchial asthma influenza vaccinations assure efficient protective antibody level and modulate the serum level of eotaxin
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