Abstract
The activity of cholinesterase and some biochemical parameters of blood such as glucose, cholesterol and phospholipids were estimated in 52 epilepsy induced females of Wister albino rats. Animals of this experiment were divided into two groups, group (I) regarded as control and group (II) administrated subcutaneously by pentylenetetrazole 100mg/kg and divided in to three sub-groups according to the time of samples collection 3 hrs, 24 hrs and 1 week. The results revealed that epilepsy induction caused a significant inhibition of serum cholinesterase activity 3 hrs after induction while in the brain, the activity of cholinesterase was significantly increased after 24 hrs Serum glucose level was significantly elevated after 3 hrs and 24 hrs of induction, total cholesterol and phospholipids were not changed. From the results obtained in this study, it can be concluded that epilepsy caused significant changes in cholinesterase activity in brain and serum in addition to the glucose level in the serum.
Highlights
Epilepsy is a devastating chronic neurological disorder that affects about 0.8% of the population worldwide
Because most of the researches concerned with epilepsy were done in the male rats and in patients treated with antiepileptic drugs, we suggest studying this disease in female without giving any drug to animals, so the objective of this study is to investigate the effect of induced epilepsy solely without any treatment on the biochemical parameters in blood and tissues of female rats
This study indicates that epilepsy induction in female caused a significant decrease in the activity of serum ChE after 3 hrs (Table1). [29] stated that inducing epilepsy in rats by pentroxifylin injection leading to decrease the ChE activity after 24 hrs of the experiment
Summary
Epilepsy is a devastating chronic neurological disorder that affects about 0.8% of the population worldwide. The clinical hallmark of epilepsy is recurrent seizures, which consist of neuronal synchronized discharges [1]. An epileptic seizure is characterized by excessive and/or hyper synchronous and usually self-limited activity of neurons in the brain [2]. Epilepsy is defined as a status of recurrent seizures [3]. During a cluster two or more seizures occur within a 24 hour time span [4]. A seizure of 30 minutes or longer duration or recurrent seizures without resumption of baseline central nervous system function are called status epilepticus [2,5]
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