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Abstract
Three groups of 6 ewes were laparotomized on day 9 of an estrous cycle (estrus = day 0) and the corporà lutea (CL) were marked with India ink. Indwelling cannulae were inserted into the uterine horn adjacent to the CL in groups 2 and 3. Group 1 was injected intramuscularly (i.m.) with corn oil twice daily on day 9. Group 2 received 750 ug 17β-estradiol (E 2) i.m. twice daily on day 9 plus intrauterine injections of indomethacin (INDO) vehicle on days 9 through 13. Group 3 received the same estrogen treatment plus the injection of 20 mg INDO twice daily on days 9 through 13. Jugular venous samples were taken once daily on days 9 through 14 progesterone analysis. At re-laparotmy on day 14, the ovaries were examined for new ovulations, and the ovary bearing the marked CL was removed. Results showed that E 2 induced premature luteal regression as indicated by decreased CL weights and plasma progesterone levels. INDO when given in conjuction with E 2 effectively blocked the luteolytic action of E 2. These results suggest that the luteolytic action of E 2 is mediated via increased prostaglandin secretion and release from the uterus.
Published Version
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