Abstract
Increased intraabdominal pressure (IAP) might occur during closure of abdominal wall defects. IAP has been shown to reduce clearance of fentanyl. MASEY et al. found acutely decreased portal flow with IAP. As it is important to also measure dactus venosus (DV) shunt and not hepatic blood flow to calculate clearance of fentanyl, we studied 6 neonatal lambs aged 4-48 hours. Fentanyl concentration was kept at 20 ng/ml. Organ blood flows were determined by a standard method, using radiolabelled microspheres. IAP was produced by a blood pressure cuff around the abdomen. Conclusion: Our study confirms that in neonatal lambs with IAP hepatic fentanyl clearance goes down. In addition we showed that DV shunt also decreases significantly, whereas no significant changes were found in portal or hepatic blood flow with IAP.
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