Abstract
Holtzman male rats were irradiated at 30, 60, 90, or 150 days of age with a lethal dose of whole-body irradiation and subsequently parabiosed to normal or castrated partners. Pairs were killed after 20 days, and testes and ventral prostates were weighed; changes in weights of ventral prostates were interpreted as due to altered secretion of androgen from interstitial cells of the testes. Irradiation caused a significant reduction in weights of the testes and ventral prostates in all age groups. The interstitial tissue of the irradiated testes was capable of responding to increased endogenous gonadotrophin secreted by the castrated partner's pituitary, but not to the same extent as in the nonirradiated animal. Effects of irradiation and repair by pairing with a castrated partner were more marked in the 30-day-old animals than in other age groups. Histologic study was made of the testes in the 30-day group. The tubular epithelium of the gonadotrophin-stimulated, irradiated testes was, in most instances, str...
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