Abstract
A primary increase in effective bone blood flow, as detected by the distribution of intravenously injected 86Rb, was produced in the bones of one lower extremity by unilateral sympathectomy in immature sheep. Animals studied at various intervals during the 18 days after sympathectomy revealed no measurable alteration in the physical bone density (Gm/cc of dried bone), percentage of ash, number or size of cortical blood vessels or, as determined by quantitative microradiography, in the percentage of surface on which formation and resorption were occurring. The experimental results suggest that a temporary primary increase in bone blood flow does not cause measurable alterations in the metabolism of the bone.
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