Abstract
The appropriate hemodialysis (HD) dialysate bicarbonate (BIC) concentration (DBIC) isn’t clear.
Highlights
The appropriate hemodialysis (HD) dialysate bicarbonate (BIC) concentration (DBIC) isn’t clear
Mean pre-HD Serum Bicarbonate Level (SBIC) was 21.2 + 8mEq/L. 11 patients were with pre-HD SBIC below the 22mEq/L threshold recommended by National Kidney Foundations (NKF)-Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines (19.3+1.4, range: 17.121)mEq/L and were considered as suffering from significant metabolic acidosis (MAC)
We were aware that high DBIC (HDBIC) may induce intradialytic alkalemia [8]
Summary
The appropriate hemodialysis (HD) dialysate bicarbonate (BIC) concentration (DBIC) isn’t clear. HDBIC increases transfer from the dialysate into the blood of CO2 and BIC, which is buffered by acids that are present before HD and organic acids produced during HD especially in states of reduced perfusion and hypoxia [10-13]. This may increase production of CO2 that is added to the transferred CO2, which are usually not associated with hypercapnia or hypoxemia [14,15], but might induce intradialytic hypercapnia in the presence of ventilation disturbances [16,17]. Higher dialysate bicarbonate concentration may correct acidosis and improve bone, muscle & nutritional state It may induce intra-dialytic metabolic alkalosis/alkalemia and/or increase bicarbonate buffering and CO2 production inducing hypercapnia in patients with disturbed ventilation. Higher dialysate bicarbonate concentration has been demonstrated to be associated with increased mortality
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biomedical Journal of Scientific & Technical Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
