Abstract
The current study involves the evaluation of factors that influence the transcorneal permeation of aqueous drops of aceclofenac ophthalmic formulation through freshly excised goat, sheep, and buffalo corneas. Aceclofenac formulation with different concentrations 0.1–0.5% (w/v) and with different pH and different preservatives, was taken into account. The amount of drug permeated from different formulations was estimated using an Franz diffusion cell. A linear increase in drug permeation was observed with increase in pH (5.5 to 7.4). The apparent permeability coefficient was found to be maximum 15.01 ± 0.45 on goat cornea and maximum transport of aceclofenac was observed at physiological pH of tears (i.e., 7). The results advocate that aceclofenac 0.5% (w/v) ophthalmic solution (pH 7.0) containing BAK (0.01%) provides maximum in vitro ocular permeability through goat, sheep, and buffalo corneas.
Highlights
The field of ocular drug delivery is one of the interesting and challenging endeavors facing the pharmaceutical scientist
All the containers were sterilized by autoclave at 121∘C for 15 min.The apparent permeability coefficient was found to be more in goat cornea compared with sheep and buffalo corneas for all concentration of aceclofenac eye drops 0.1% to 0.5%
The apparent permeability coefficient was found to be more in goat cornea compared with sheep and buffalo cornea for all concentration of aceclofenac eye drops 0.1% to 0.5%
Summary
The field of ocular drug delivery is one of the interesting and challenging endeavors facing the pharmaceutical scientist. Topical delivery into the conjunctival cul-de-sac is by far the most common route of ocular drug [2] Absorption from this site may be corneal or noncorneal. Nonsteroidal anti-inflammatory drugs (NSAIDs) are recommended for treatment of various pains, inflammatory conditions of eye, osteoarthritis, and rheumatoid arthritis. Aceclofenac eye drop is not available in market so in this we use a novel approach to formulate aceclofenac eye drops to reduce eye inflammation These drugs are used topically varying widely in inhibition of intraoperative miosis, management of postoperative inflammation, treatment of seasonal allergic conjunctivitis, prevention and treatment of cystoid macular edema, and the control of pain after photo refractive keratectomy. 3.5 cm (a) Goat eye (b) Sheep eye (c) Buffalo eye Thickness 0.68 mm Thickness 0.85 mm Thickness 1.15 mm (d) Goat cornea (e) Sheep cornea (f) Buffalo cornea
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