Abstract
The effect of in utero exposure to diethylstilbestrol (DES) on the immune system was investigated. Mice were exposed to DES through maternal dosing (0.1 mg/kg body wt) on Day 16 of gestation. Parameters of cell-mediated and humoral immune function were evaluated between 7 and 9 weeks of age. DES slightly suppressed cellmediated immune function in both males and females. In contrast, a sex specificity was noted in humoral immune function with enhanced antibody responses to a T-independent antigen in males and either no effect or slight suppression in females.
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