Abstract
Objective To explore the effects of in situ gelling collagen on restoration of neuron function after spinal cord injury in rats. Methods Fifteen healthy female SD rats were randomly divided into collagen group, control group and sham operation group. Contusive spinal cord injury models were made by improved Allen's weight drop method. In collagen group and control group, collagen and PBS solutions were respectively injected into epicenter using micro-syringes, and allowed for gel formation in situ at body temperature. BBB loco-motion scores were tested once per week for 6 weeks. After 6 weeks, immunohistochemistry was carried out to as-sess glial scar formation and axon regeneration. Results BBB scores of collagen group were significantly higher than that of control group from 5th week. Fewer glial scars were found in injured area in collagen group and more axons regenerated into injured area than that of control group. Conclusion In situ gelling collagen can inhibit the formation of glial scars in injured area and promote axon regeneration into injured area. Collagen might be a promising injectable material for the repairing of spinal cord injury. Key words: Collagen; Spinal cord injury; Axon regeneration; Glial scar
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