Effect of Improvement in Sarcopenia on Functional and Discharge Outcomes in Stroke Rehabilitation Patients.

Tatsuya Matsushita,Kana Oishi,Yuka Okazaki,Shiori Taguchi,Yoshiharu Tokunaga,Tatsuya Fujii,Anna Yamanouchi,Ryusei Nakashima,Shinta Nishioka,Shinya Onizuka

doi:10.3390/nu13072192

Abstract

This cross-sectional study investigated the proportion of patients’ recovery from sarcopenia status and the relationship between improvement in sarcopenia (IS) and function and discharge outcome in hospitalized patients with stroke. This study included patients with stroke, aged 65 years or more, with a diagnosis of sarcopenia, who were admitted to a convalescent rehabilitation ward. Sarcopenia was diagnosed according to the Asian Working Group for Sarcopenia 2019 criteria. Patients were divided according to the presence or absence of sarcopenia at discharge: IS group and non-improvement in sarcopenia (NIS) group. Among the 227 participants (mean age: 80.5 years; 125 females), 30% (69/227) of the patients were in the IS group, while 70% (158/227) were in the NIS group. The IS group showed a higher Functional Independence Measure (FIM) than the NIS group (median 112 vs. 101, p = 0.003). The results demonstrated that IS was independently associated with higher FIM (partial regression coefficient, 5.378; 95% confidence interval (CI), 0.709–10.047). The IS group had higher odds of home discharge than the NIS group (odds ratio, 2.560; 95% CI, 0.912–7.170). In conclusion, recovery from sarcopenia may be associated with better function in patients with stroke.

Highlights

Sarcopenia, a progressive and systemic skeletal muscle disorder, increases the risk of adverse clinical outcomes, including falls, fractures [1,2], physical disability [3] and poor quality of life [4]
(7 patients transferred to aninacute care hospital and 11 patients the 245 participants first enrolled the study, those who met the exclusion with metallic implantation)
The median number of days that7 sarcopenic status was sarcopenic status of all participants was measured within days of admission and within measured afterofadmission

Summary

Introduction

Sarcopenia, a progressive and systemic skeletal muscle disorder, increases the risk of adverse clinical outcomes, including falls, fractures [1,2], physical disability [3] and poor quality of life [4]. Sarcopenia is a syndrome that can be divided into age-related, disease-related, inactivity-related and poor nutrition-related forms [5]. More attention has been given to research about the modifications in the characteristics of the muscle tissue after a stroke [8]. In this context, stroke-related sarcopenia is characterized by a rapid decline in muscle mass after onset, muscle fiber-type shifts, determining bilateral differences in the physical and functional performance of brain lesions, impaired feeding and complex systemic metabolic changes [7,9]. Our previous study demonstrated that sarcopenia is a predictor of poor

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Conclusion