Abstract
Positron emission tomography with 11C-palmitate and single photon imaging with terminally radioiodinated fatty acid analogues (123I-FFA) were evaluated for the non-invasive assessment of regional myocardial fatty acid metabolism during ischaemia. Decreased uptake of tracer and delayed clearance of activity in the ischaemic myocardium were reported for both 11C-and 123I-labelled compounds. However, since during ischaemia both myocardial blood flow and oxidative metabolism are reduced concomitantly, either factor can be responsible for the changes observed. Experimental preparations in which fatty acid metabolism can be modified independently of flow are helpful for the characterization of the relationship between metabolism and myocardial kinetics of labelled fatty acids. Results obtained during flow-independent inhibition of fatty acid oxidation include the following observations: - In dogs with controlled coronary perfusion the rate of clearance of 11C-palmitate activity is decreased during diminished delivery of oxygen, regardless of whether myocardial perfusion is concomitantly reduced or not. - In isolated rabbit hearts perfused at normal flow, the extraction of 123I-FFA is decreased during hypoxia. - During pharmacological inhibition of fatty acid oxidation the deiodination of 123I_FFA is markedly reduced in rat hearts in vivo and in vitro.
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