Abstract
It was shown previously that peripheral lymph node cells secrete an antigen-specific factor after short-term contact with antigens in vivo [2, 3]. Similar mediators were found in the serum of animals 3-6 h after immunization or in a cell culture in vitro by other workers [7, 8]. Injection of immune lymph node factors (ILNF) into intact animals led to changes similar to those found after injection of the antigens themselves. Just like antigen, ILNF induced a decrease in antigen-specific stimulating activity and an increase in antigen-nonspecific suppressor activity in bone marrow cells [2, 3]. Meanwhile injection of ILNF and antigens (sheep's red blood cells or P-815 mastocytoma cells) led to a three to sixfold increase in the intensity of humoral and cellular reactions [i].
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