Abstract
Fe–Mn-based degradable biomaterials (DBMs) are promising candidates for temporary implants such as cardiovascular stents and bone fixation devices. Identifying their mechanical properties and biocompatibility is essential to determine the feasibility of Fe–Mn-based alloys as DBMs. This study presents the tensile properties of two powder metallurgical processed Fe–Mn-based alloys (Fe–28Mn and Fe–28Mn-3Si, in mass percent) as a function of immersion time in simulated body fluid (SBF). In addition, short-term cytotoxicity testing was performed to evaluate the in vitro biocompatibility of the sintered Fe–Mn-based alloys. The results reveal that an increase in immersion duration deteriorated the tensile properties of both the binary and ternary alloys. The tensile properties of the immersed alloys were severely degraded after being soaked in SBF for ≥45 days. The ion concentration in SBF released from the Fe–28Mn-3Si samples was higher than their Fe–28Mn counterparts after 7 days immersion. The preliminary cytotoxicity testing based on the immersed SBF medium after 7 days immersion suggested that both the Fe–28Mn-3Si and Fe–28Mn alloys presented a good biocompatibility in Murine fibroblast cells.
Highlights
Medium after 7 days immersion suggested that both the Fe–28Mn-3Si and Fe–28Mn alloys presented a good biocompatibility in Murine fibroblast cells
Fe–based alloys proposed for degradable biomaterials (DBMs) are commonly designed for temporary implants such as cardiovascular stents and bone fixation devices [1,2,3]
The majority of the available data on mechanical performance of Fe–based DBMs has implied that the mechanical properties of fabricated Fe–based DBMs were adequate to support the healing of diseased tissues [1,18,19]
Summary
Fe–based alloys proposed for degradable biomaterials (DBMs) are commonly designed for temporary implants such as cardiovascular stents and bone fixation devices [1,2,3]. The available data, cannot reflect the real mechanical properties of Fe–based implants after serving in the human body for a certain period This is because current data were from the initial mechanical properties of the as-fabricated Fe–Mn-based alloys without implanting in a physiological environment. Metals 2016, 6, 309 of mechanical properties of Fe–Mn-based DBMs in a corrosive physiological environment In this case, it is important to investigate the evolution of the mechanical properties of the biomaterials implanted in the human body as a function of implanted time, in order to better predict the life span of the designed Fe–Mn-based DBMs. Biocompatibility is a unique feature of biomaterials over any other materials. A short-term in vitro cytotoxicity of the sintered Fe–Mn-based alloys was evaluated
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