Abstract
Imidacloprid is one of the most widely used insecticides in the world. Present study is indicating the effects of orally administered imidacloprid on biochemical blood profile and histological parameters on male rat’s liver. Dose response with respect to different time intervals was evaluated on different groups of rats. Signs of acute/sub-acute poisoning were observed and severity of these findings in the imidacloprid treated rats was found to be dose dependent. Higher concentrations of imidacloprid increased the amount of cholesterol in all the treated groups, the HDLlevel decreased and the Level of LDLin treated group was higher when these were compared with control rats. The toxicity of the pesticide leads to higher levels of AST and ALTin time and dose dependent manner as compared to the control rats. Moreover, a high concentration of imidacloprid dose transiently increased and then slightly decreased the concentration of total serum proteins, globulins and serum albumin. Additionally, histopathological examination of liver revealed bile duct hyperplasia along with degenerative changes in hepatocytes and the severity was found to be dose dependent.
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