Abstract
This study aims to determine the effect of giving Iles-iles synbiotic effervescent tablets to decrease blood sugar levels of hyperglycemic white rats and find out the lowest dose of effervescent tablets in decreasing blood sugar levels. This study used the Completely Randomized Design (CRD) with single factor (dose of Iles-iles synbiotic effervescent tablet) with 4 levels (dose 0.045 gram/day (½ normal dose), dose 0.09 gram/day (normal dose), dose 0.18 gram/day (2X normal dose) and Control (without treatment dose). The analysis carried out was blood sugar levels and rat body weight. The administration of Iles-iles synbiotic effervescent tablets can reduce blood sugar levels in white mice but does not affect changes in the weight of white mice. The biggest decrease in blood sugar levels in white rats for synbiotic month was obtained from the administration of a dose of 0.18 grams/day (normal 2X dose) which was as much as 49.16% The administration of effervescent tablets in the fourth week with a normal dose of 0.09 grams/200 grams of weight has been able to reduce blood sugar levels in white rats to normal levels. 
Highlights
Diabetes mellitus is a chronic disease caused by the inability of the body to produce insulin or the ineffective use of insulin production, which is characterized by high levels of sugar in the blood
An increase in blood glucose which exceeds the normal level often follows within Diabetes Mellitus patients [1]
Dietary fiber that can provide this function is soluble fiber, such as pectin, guar gum, and glucomannan that can be abundantly found in vegetables, fruits, and tubers [2]
Summary
Diabetes mellitus is a chronic disease caused by the inability of the body to produce insulin or the ineffective use of insulin production, which is characterized by high levels of sugar in the blood. An increase in blood glucose which exceeds the normal level often follows within Diabetes Mellitus patients [1]. The factors that affect blood glucose levels are various such as the lack of exercise, stress, obesity, poor treatment of medication, and shortage of fiber. The increase in the amount of food consumed one of them tends to consume fast food which is usually high in carbohydrates and low in fiber. Fiber can reduce the efficiency of carbohydrate absorption which will cause a decrease in insulin response. The work of the pancreas will be easier and it will improve the function of the pancreas in producing insulin. Dietary fiber that can provide this function is soluble fiber, such as pectin, guar gum, and glucomannan that can be abundantly found in vegetables, fruits, and tubers [2]
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