Abstract
Treatment of rats with indomethacin, 1.5 mg/kg per day, for one week, significantly reduced the number of β-adrenoceptors in the heart without altering their affinity for the specific β-adrenergic ligand. In indomethacin-treated rats there was a reduction in the cardiac response to epinerphrine in vivo as indicated by a shift to the right of the epinephrine dose-heart rate response curve. These results support a possibl interference by indomethacin in β-adrenoceptor-mediated effects.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
