Effect of Ibandronate Therapy on Serum Chemerin, Vaspin, Omentin-1 and Osteoprotegerin (OPG) in Postmenopausal Osteoporotic Females.

Saba Tariq,Muhammad Shahzad,Shahad Abduljalil Abualhamael,Sundus Tariq

doi:10.3389/fphar.2022.822671

Abstract

Osteoporosis is a condition in which bone mineral density is reduced due to altered bone microstructure, which results in increased skeletal fragility and incidence of various types of fractures. Adipokines such as chemerin, vaspin, omentin-1 and osteoprotegerin are involved in bone remodeling. The current study was designed to determine the changes in circulating chemerin, vaspin, omentin-1, and osteoprotegerin levels after treatment with oral ibandronate 150 mg in postmenopausal osteoporotic females. The present study enrolled 107 postmenopausal osteoporotic females from a tertiary care hospital in Faisalabad, Pakistan, based on stringent inclusion and exclusion criteria. Sixty-six healthy postmenopausal, non-osteoporotic females with no systemic illness were chosen from the general population. The assessment of bone mineral density (BMD) was done using a DEXA scan. Serum levels of chemerin, vaspin, omentin-1 and osteoprotegerin were estimated using commercially available enzyme-linked immunosorbent assay kits. The collected data were analyzed with the Statistical Package for Social Sciences (SPSS) version 24. Following 6 months of ibandronate treatment, there was a significant decrease of 24.24% (p < .033) in serum chemerin levels, as well as a significant increase in serum vaspin levels 343.32% (p < .001) and osteoprotegerin levels 19.57% (p < .001), with no significant change in omentin-1 levels. Thus, an increase in serum chemerin levels and a decrease in serum vaspin and osteoprotegerin levels could be implicated in osteoporosis.

Highlights

Osteoporosis is a chronic bone disease marked by a decreased bone mineral density (BMD) because of altered bone microstructure, leading to increased skeletal fragility and fracture risk (Falaschi and Giordano, 2017)
Novel adipokines, including leptin, chemerin, omentin, vaspin, and visfatin, have many physiological functions in the body, and the researchers are greatly interested in exploring the relationship between these adipokines and bone homeostasis (Liu et al, 2013)
There was no significant difference in serum vaspin and omentin-1 levels (Table 1)

Summary

Introduction

Osteoporosis is a chronic bone disease marked by a decreased bone mineral density (BMD) because of altered bone microstructure, leading to increased skeletal fragility and fracture risk (Falaschi and Giordano, 2017). In Pakistan, numerous factors like illiteracy, financial instability, and sedentary lifestyle increase osteoporosis risk among women. The diagnosis modalities such as DEXA scan are not accessible, and treatment is expensive (Tariq et al, 2017). Novel adipokines, including leptin, chemerin, omentin, vaspin, and visfatin, have many physiological functions in the body, and the researchers are greatly interested in exploring the relationship between these adipokines and bone homeostasis (Liu et al, 2013). A mice study observed chemerin involvement in bone loss, and the administration of chemerin receptor antagonist CCX832 resulted in inhibition of bone loss. It showed chemerin could increase osteoclastic activity (Ramos-Junior et al, 2017). In contrast to this study, a recent study discovered that CMKLR1 knockout mice have lower trabecular bone mass (Zhao et al, 2019)

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Conclusion