Abstract
Villi from mature human placentas were maintained in organ culture in 26 per cent oxygen and showed little morphologic change over a period of 10 days; others, grown in 6 per cent oxygen, showed variable syncytial degeneration and a marked increase in the number of cytotrophoblastic cells. Under hypoxic conditions the incorporation of tritiated thymidine into cytotrophoblastic cells was much increased and labeling of syncytial nuclei with this compound was considerably greater than in fully oxygenated villi. It is suggested that the cytotrophoblast proliferates under conditions of hypoxia in an attempt to repair damaged syncytium and that the findings mimic those frequently seen in placentas from toxemic patients.
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