Effect of hypoxia on postoperative prognosis of radical cystectomy in patients with bladder cancer

Abstract

Objective To explore the effect of hypoxia on postoperative prognosis of radical cystectomy in patients with bladder cancer.Methods A total of 66patients with bladder urothelial cancer undergoing radical cystectomy surgery were divided into hypoxia group(OH group,n=19)and the normoxic group(NS group,n=47).Immunohistochemical examination was used to examine the expression of HIF-1αand CD105-assessed microvessel density(MVD).The survival of the patients was followed up and the clinical data of the two groups were compared.Kaplan-Meier analysis was used for analyzing the survival of the two groups,and a Cox model was established to analyze correlation of each variable with the survival time. Results In the OH group,the positive rate of HIF-1αwas 89.5%(17/19)in the tumor tissues,the MVD value was 53.1± 19.0,and the median survival time was 56months;the corresponding values in the NS group were 66.0%(31/47),40.1± 15.2,and 82months,respectively.The clinical stages,Hb levels,HIF-1αexpression,and MVD values were significantly different between the two groups(P0.05).Advanced tumor stage,hypoxia state,high HIF-1αexpression and high MVD value in tumor tissues were associated with a shorter survival of patients,and high Hb was associated with a longer survival of patients(P0.05or P0.01).Conclusion Hypoxic state can lead to increased HIF-1αexpression and microvessel density in bladder cancer tissues,which is harmful for patient prognosis.