Abstract
Effect of hypotension on levels of antidiuretic hormone (ADH) in plasma was investigated in dogs. Mild-to-severe hypotension was induced either by intravenous administration of sodium nitroprusside or by hemorrhage. ADH titers in plasma were measured before and after the induction of hypotension. Marked rises of the concentrations of ADH in plasma were observed following a fall of arterial blood pressure. The physiological meanings of these rises were discussed.
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