EFFECT OF HYPOSENSITIZATION THERAPY ON NASAL ALLERGY

Abstract

The hyposensitization therapy was carried out on 44 allergic rhinitis patients. The released human leukocyte histamine to house dust antigen, S-IgE, S-IgG, specific nasal mucous mem-brane sensitivity test to house dust antigen, noe-specific nasal mucous membrane sensitivity test to serotonin disc and antigen neutralizing capacity were measured both before and after a year of hyposensitization, and the results were presented, and discussed to make objective criteria for the effect of hyposensitization therapy.The following were the results of this study.1. Antigen neutralizing capacity after a year of hyposensitization therapy proved to be greater than those before and, the significant correlation between the inceasing antigen neu-tralizing capacity and the effect of hyposensitization therapy was confirmed.2. S-IgE level and leukocyte histamine release in the patients with allergic rhinitis did not change generally after hyposensitization therapy.3. After a year hyposensitization therapy, significant in allergic rhinitis patients increase in S-IgG level occurred, but it had no significant correlation with clinical symptoms.4. Non-specific nasal mucous membrane sensitivity did not change, but specific nasal mucous membrane sensitivity decreased and correlated significantly with the effect of hyposensitization therapy.