Abstract
Hypophysectomy has been shown to affect the pattern of urine formation and excretion by the euryhaline killifish, Fundulus kansae. Changes noted in fresh water include (a) a drop in urine volume, (b) a rise in osmotic pressure, due in part to increased concentrations of sodium and potassium in the urine, and (c) a marked increase in the time required to shut off urine flow when transferred suddenly from fresh water to sea water. Hypophysectomized animals in fresh water also show a slight but consistent reduction in the osmotic pressure of the serum. Pre-exposure to saline increases the ability of hypophysectomized animals to respond to an osmotic challenge, but they do not respond as well as their controls.
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