Abstract
Intestinal active and passive transport of phosphate (P i) was studied in hypophysectomized (HX) and intact rats using the in situ intestinal loop technique. Hypophysectomy resulted in a significant reduction of total P i absorption under active transport conditions. However, when transport data were expressed on the basis of mucosal mass, the reduction was not apparent. Under passive transport conditions, net P i absorption was lower in the HX rats even after correction for the decrease of mucosal mass. Administration of bovine growth hormone (bGH) did not change the intestinal P i absorption in the HX rats. These results indicate that a decrease in mucosal mass following hypophysectomy is one of the factors that causes a decrease of intestinal P i absorption.
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