Abstract
Effects of hypocalcemia on Ca<sup>2+</sup> metabolism of microsomes from rat kidney cortex were studied. Microsomal activities of Ca<sup>2+</sup>-ATPase, Mg<sup>2+</sup>-ATPase and (Na<sup>+</sup>+K<sup>+</sup>)-ATPase increased 30–33 days after Ca<sup>2+</sup> restriction or low Ca<sup>2+</sup>· vitamin D depletion, but alkaline phosphatase activity decreased. Calcium repletion in diet and injection of lα-hydroxycholecalciferol or 1,25-dihydroxycholecalciferol were partially successful in returning Ca<sup>2+</sup>-ATPase and Mg<sup>2+</sup>-ATPase activity, but not (Na<sup>+</sup>+K<sup>+</sup>)-ATPase and alkaline phosphatase activity, to normal. Correlations between serum Ca<sup>2+</sup> level and both ATPase activities were significant. ATP-dependent Ca<sup>2+</sup> uptake of microsomes was not affected by hypocalcemia and vitamin D metabolites.
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