Abstract
To investigate whether increased blood prolactin concentration affects epididymal cyclic AMP (adenosine 3′,5′-cyclic monophosphate) levels during hyperthermic stress, a study was conducted on 40 Sprague–Dawley male rats divided into four equal groups. Two groups were injected intraperitoneally with bromocriptine, a potent inhibitor of prolactin release. Under identical experimental conditions, one group was subjected to hyperthermic stress, and the other group was maintained at room temperature. Two additional groups were injected with a control vehicle; one group was subjected to hyperthermic stress, and the other group was kept at normal body temperature. Blood samples were analyzed for serum prolactin, and epididymal fat pads were assayed for cyclic AMP. Serum prolactin levels increased significantly (p < 0.01) in hyperthermic rats, but this effect was suppressed completely by bromocriptine. Cyclic AMP levels were increased (p < 0.01) during elevated body temperature in all animals examined, with no significant difference (p > 0.05) occurring between the nonbromocriptine-treated and bromocriptine–prolactin-suppressed groups. This investigation suggested that elevation of epididymal fat cyclic AMP during hyperthermia is not the result of increased prolactin levels.
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