Effect of hyperthermic intraperitoneal perfusion on blood coagulation in patients undergoing laparoscope-assisted radical surgery for gastric cancer

Abstract

Objective To evaluate the effect of hyperthermic intraperitoneal perfusion on blood coagulation in patients undergoing laparoscope-assisted radical surgery for gastric cancer. Methods Forty patients of both sexes, aged 40–60 yr, weighing 50–80 kg, of American Society of Anesthesiologists physical status Ⅰ or Ⅱ, undergoing elective radical surgery for gastric cancer, were equally randomized into control group(group C)and hyperthermic intraperitoneal perfusion group(group HIP). The patients were treated with hyperthermic intraperitoneal perfusion for 1 h after the end of the radical surgery in group R. Before induction of anesthesia(T0), immediately before hyperthermic intraperitoneal perfusion(T1), and at 1 h of hyperthermic intraperitoneal perfusion(T2), venous blood samples were collected, blood coagulation was measured using thromboelastography, and the reaction time, coagulation time, α angle and maximal amplitude were recorded. Results Compared with group C, no significant change was found in blood coagulation parameters at T0 and T1(P>0.05), the reaction time and coagulation time were significantly increased, and α angle and maximal amplitude were decreased at T2 in group HIP(P<0.05). Conclusion Hyperthermic intraperitoneal perfusion can improve blood coagulation in the patients undergoing laparoscope-assisted radical surgery for gastric cancer. Key words: Chemotherapy, cancer, regional perfusion; Blood coagulation tests; Laparoscopy; Stomach neoplasms