Abstract
The interaction of 43°C hyperthermia and X-irradiation was compared in vitro in two cell lines: Chinese hamster ovary (HA- 1) and mouse mammary sarcoma (EMT- 6). In HA- 1 cells the sequence of heating followed by X-irradiation resulted in appreciably more sensitization than the opposite sequence; in EMT- 6 cells the opposite occurred. When time at 37°C was introduced between the two treatments, the degree of interaction was reduced, depending upon sequence and the duration of the 37°C time interval. In both cell lines, maximum toxicity was seen if the two treatments followed each other immediately.
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