Abstract
We examined the effect of experimental hyperphenylalaninemia in rats on Na + + K +-ATPase activity in various subcellular fractions from brain. The hyperphenylalaninemia was induced by treatment with phenylalanine plus p-chlorophenylalanine. The data indicated that the activity of Na + + K +-ATPase in mitochondria and synaptosomes from brains of hyperphenylalaninemic rats was significantly reduced. We suggest that the reduction in ATPase activity is related to the reduction in unsaturated fatty acid in brain phospholipids known to occur in experimental hyperphenylalaninemia. In view of the central role of ATPase activity in neuronal function, it is possible that the reduction in the ATPase activity may be implicated in the functional abnormalities observed in experimental hyperphenylalaninemia and perhaps in the genetic disease phenylketonuria in humans.
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