Abstract
Abstract The effect of a high cholesterol diet on plasma lipids, platelet aggregation, vessel pathology and arterial blood pressure was studied in rabbits. In addition, the effect of stress (swimming or orthostasis) on these parameters was tested and compared with data obtained from control rabbits. The high cholesterol diet resulted in high plasma cholesterol and triglyceride levels and an elevated arterial blood pressure. Platelet aggregation (measured with a photometric procedure) was significantly enhanced in the hyperlipidemic state. An enhanced platelet aggregation was also noted in rabbits on standard diet during stress situations. Platelet aggregation was most pronounced when stress was applied in hyperlipidemic rabbits. Atheromatosis of the aorta, renal, femoral, coronary and carotid arteries was noted in rabbits on a high cholesterol diet. Strips of atheromatotic aortas revealed a significant decline in yield stress. The high cholesterol rabbits may represent a reproducible model for induction of atheromatosis, in wich platelet aggregation, hemodynamics, blood lipids and vascular pathology can be studied and correlated.
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