Abstract
Parkinson's disease (PD) is a common neurodegenerative movement disease affecting a large number of people worldwide. In animals, the intracranial or systemical application of the neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) can result in severe injury to the nigrostriatal dopaminergic system. Hypericum perforatum is a plant generally used as an antidepressant that also has anti-inflammatory and antioxidant properties. Hypericum perforatum has been used to lessen the mild to moderate symptoms of depression. The present study was done to find the effect of Hypericum perforatum methanolic extract pretreatment and post-treatment on behavioral studies in MPTP induced Parkinson’s disease model. The behavioral assessments were performed with a forced swim test, pole test, tail suspension test, and catalepsy test. Hypericum perforatum extract ameliorated depressive-like behavior better in post-treatment as compared with pretreatment group in MPTP model of Parkinson's disease. It can be said that Hypericum perforatum methanolic extract might be a therapeutic agent for the treatment of PD, but further clinical studies are required.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Research in Pharmaceutical Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
