EFFECT OF HYOSCINE-N-BUTYL BROMIDE ON CERVICAL EFFACEMENT AND DILATION DURING NORMAL LABOR

Abstract

Background: Labor is a multifactorial and dynamic process which involves myometrial contraction, cervical ripening and dilation and the expulsion of the fetus and placenta in an orderly manner. Objective: To study the efficacy and safety of Hyoscine-N-butyl bromide (HNBB) on enhancement of cervical effacement and dilation during normal labor, duration of labor and mode of delivery compared to the control group. Patients and methods: This was a randomized un blinded controlled trial was conducted on pregnant women in active phase of first stage of labor from those attendant labor ward of Obstetrics and Gynecology Department at Sohag General Hospital. 200 pregnant women were recruited to this study and divided into 2 equal groups. Study group received Buscopan 20 mg diluted in 9 ml saline slowly intravenously and control group received 10 mL normal saline. Results: The mean duration of active phase of labor in the study group and control group was found to be 186 and 338 minutes respectively (p value = 0.0001). No significant difference was observed in the duration of second and third stage of labor, mode of delivery, birth weight, Apgar score and color of the liquor in both the groups. Conclusion: Administration of HNBB i.v. significantly reduced the duration time of cervical dilation in the active phase of first stage of labor, thereby reducing the total duration of labor. Hyoscine –N- butyl bromide is a new aid in the management of uncomplicated labor for a convenient shorter and safer physiological delivery making it more tolerable for the mother.