Effect of hydrophilic polymer and binder on drug release of metformin HCl sustained release tablet

Abstract

To develop an oral sustained release Metformin HCl tablet by wet granulation technique, using different grades of hydroxyl propyl methylcellulose (HPMC) in different concentration and by varying binder concentrations. Metformin HCl was received as gift sample while all other excipients of analytical grade were procured from the market. Formulation optimization was done by three ways to select optimum formula for preparing sustained release matrix tablet. Trail batches were prepared by altering the hydrophilic polymers as well as binder concentration and all the batches are evaluated for pre-compression and post-compression parameters. In first step, concentration of HPMC K4M is optimized by preparing three trial batches while in second step and third step concentration of HPMC K15M and HPMC K100M is optimized by next three-three batches respectively. Amount of HPMC is optimized to 240mg. The drug release of all the optimized HPMC batches were evaluated for in-vitro drug release study in pH 6.8 phosphate buffer solution in comparison with marketed formulation. Drug identification was performed by melting point determination, FTIR, UV and solubility determination. After pre-compression and post-compression evaluation we get the appropriate result in B3, B6 and B9 batches.