Abstract
AbstractThe aerobic responses of the rabbit cornea to commonly used sterilization solutions for applanation tonometers in clinical practice were measured. Hydrogen peroxide (3.0, 3.75, 4.8, and 7.5%) and sodium hypochlorite (0.5 and 1.0%) solutions were each applied to six corneas. Significant increases (p<0.01, paired Student's t-test) in oxygen uptake rates (41.2, 48.2, 51.7, and 79.2% increases with 3.0, 3.75, 4.8, and 7.5% hydrogen peroxide solutions, respectively) occurred 1 min after exposure. The oxygen uptake rate returned to baseline 10 min after exposure at all concentrations. Significant decreases occurred 30 and 60 min after exposure to 7.5% hydrogen peroxide. Decreases in corneal oxygen uptake rate occurred after exposure to 0.5 and 1.0% sodium hypochlorite. Hydrogen peroxide 3.0% solution caused the least significant changes in corneal oxygen uptake rate of all the solutions tested.
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