Abstract

Hydrated fullerene C 60 (HyFnC 60 ) is a symmetrical molecule of C 60 Buckminster fullerene surrounded by a water shell obtained by an original technique. It can act as an antioxidant or a pro-oxidant in various biological objects, depending on the conditions. In this study we added HyFnC 60 at a range of concentrations obtained by a method of serial dilutionswith vigorous shaking at each step to whole undiluted blood of healthy donors and hospital patients with COPD and examined lucigenin-enhanced blood chemiluminescence. We have found that HyFnC 60 at concentrations of 2.5 ´ 10 – 6 M, 2.5 ´ 10 – 7 M, 2.5 ´ 10 – 17 M, and 2.5 ´ 10 – 19 M increased lucigenin-dependent chemiluminescence in heathy donors’ blood while in blood of patients with COPD it had an opposite effect. This can be interpreted as in healthy donors’ blood reactive oxygen species (ROS) generation is enhanced by HyFnC 60 while in patients with a chronic inflammatory disease with already increased ROS generation it is attenuated. This indicates that HyFnC 60 preparations even in ultra-high dilutions may play the role of a tuner of the processes with ROS participation. Probable reasons of such action of HyFnC 60 on human blood even in ultra-high dilutions are discussed.

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