Abstract
Objective To investigate the effect of the promoting blood circulation to Huoxue-Huayu decoction combined with carbogen for diabetic retinopathy (DR). Methods A total of 76 DR patients who met the inclusion criteria were divided into 2 groups by random number table method, 38 cases in each group. Both groups were given the routine hypoglycemic treatment, and the control group added the treatment of calcium oxybenzosulfonate tablets, wihle the treatment group added the Huoxue-Huayu decoction. Both groups were treated for 2 months. The FPG, 2 hPG and HbAlc were detected by automatic biochemical analyzer. The serum levels of hypersensitive c-reactive protein (hs-CRP) and Serum cystatin C (Cys C) were detected by immuno-transmission turbidimetry. The serum homocysteine (Hcy) was determined by radioimmunoassay. The serum transforming growth factor β1 (TGF-β1) and il-6 were detected by the ELISA. The serum glutathione peroxidase (GSH-Px) was detected by colorimetry. The Fluorescence fundus angiography was used to detect the area of macular edema, the number of microangiomas and the area of bleeding focus. The Visual field defect was examined under normal pupils to evaluate the clinical efficacy. Results The total effective rate was 84.2% (32/38) in the treatment group and 60.5% (23/38) in the control group, with statistically significant difference (χ2=5.331, P=0.021). After treatment, the serum levels of FPG and HbA1c in the treatment group were significantly lower than those in the control group (t values were 2.059 and 2.081, respectively, all Ps<0.05). The Serum Hcy, Cys C, hs-CRP, TGF-β1, IL-6 levels in the treatment group were significantly lower than those in the control group (t values were 4.575, 2.799, 19.520, 6.614, 10.644, P<0.05 or P<0.01), while the GSH-Px levels were significantly higher than the control group (t=10.483, P<0.01). Compared with the control group after treatment, the number of microangiomas in the treatment group decreased, the area of bleeding focus decreased, the gray scale value of the visual field decreased, and the area of macular edema decreased (t values were 7.543, 3.923, 4.957 and 6.691, all Ps<0.01). Conclusions The Huoxue-Huayu decoction combined with carbogen can reduce the degree of visual field defect , reduce the inflammatory reaction and improve the clinical effect for DR patients. Key words: Diabetic retinopathy; Huoxue-Huayu decoction; Capotkin; Macular edema; Eye hemorrhage; Visual fields
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