Effect of human papillomavirus detection on screening of cervical lesions

Abstract

Objective To understand human papillomavirus(HPV)infection status in 1002 married women in Luohu community,in Shenzhen,and to investigate the value of HPV detection on screening of cervical lesions.Methods Polymerase chain reaction(PCR) HPV method was used to detect HPV type,the positive cases were examined by liquid-based cytology test (LCT).A biopsy under colposcopy was performed in women whose LCT test ≥ atypical squamous cells of determined significance(ASC-US).Results Sixty-one cases were positive in 1002 cases,the positive rate of HPV infection was 6.09％,HPV 16,58,18,6,51,52 and 66 type were more common.Women whose LCT results ≥ASC-US were 28 cases.Biopsy under colposcope diagnosis of cervical intraepithelial neoplasia(CIN) Ⅰ in 18 cases,CIN Ⅱ in9 cases,CIN Ⅲ in 3 cases,cervical cancer in 1 case.Conclusions About 6.09％ married women in Luohu community,in Shenzhen,have HPV infection,type 16,58,18,6,51,52 and 66 are more common.HPV combined with LCT and biopsy under colposcopy can effectively detect cervical lesions,that will has important clinical application value in early diagnosis and treatment of cervical intraepithelial neoplasia and cervical cancer. Key words: Human papillomavirus; Liquid-based cytology test; Colposcopy; Cervical intraepithelial neoplasia; Cervical cancer; Screening