Effect of human immunoglobulin combined with azithromycin sequential therapy on immunologic function in children with neonatal infectious pneumonia

Abstract

Objective To investigate the effect of human immunoglobulin combined with azithromycin sequential therapy on T lymphocyte subsets and serum procalcitonin (PCT) and interferon-γ (IFN-γ) levels in children with neonatal infectious pneumonia (NIP). Methods From June 2013 to November 2016, 86 children with NIP in our hospital were selected, and were divided into control group and observation group according to different treatment regimens, 43 cases in each group. The control group was treated with azithromycin sequential therapy, and the observation group was treated with human immunoglobulin + azithromycin sequential therapy. After the end of treatment, treatment effect, disappearance time of symptoms and signs, and adverse reactions of the two groups were statistically analyzed, and T lymphocyte subsets (CD4+/CD8+, CD4+, CD3+, CD8+), serum PCT and IFN-γ levels were compared before and after the end of treatment. Results The total effective rate of treatment of the observation group [95.35% (41/43)] was significantly higher than that of the control group [79.07% (34/43)], with statistically significant difference (P 0.05); there was no statistically significant difference in CD8+ level between the two groups after treatment (P>0.05); compared with the control group, the CD4+/CD8+, CD4+, CD3+ levels in the observation group were higher after treatment (P 0.05); compared with the control group, the serum PCT level was significantly lower and the IFN-γ level was significantly higher in the observation group (P 0.05). Conclusion Human immunoglobulin combined with azithromycin sequential therapy in children with NIP can significantly improve the T lymphocyte subsets, reduce the serum PCT level, increase the serum IFN-γ level, effectively promote the recovery of symptoms and signs of children, with higher safety and more significant effect. Key words: Human immunoglobulin; Azithromycin; Sequential therapy; Neonatal infectious pneumonia; T lymphocyte subsets; Procalcitonin; Interferon-γ