Abstract
Background To observe the effect of Huaiqihuang granules combined with comprehensive nursing intervention on children with primary nephrotic syndrome (PNS) and its effect on renal function index. Methods A total of 104 patients were included, and the patients were randomly divided into two groups, with 52 cases in each group. The control group was treated with glucocorticoid, and the study group was treated with Huaiqihuang granules. The clinical efficacy of the two groups was observed. The levels of TG, TC, EGFR, 24 h UTP, BUN, Scr, IgA, IgG, IgM, IFN-γ and TNF-α were compared between two groups before and after treatment. The incidence of adverse reactions and recurrence rate after treatment were compared between the two groups. Results The effective rate of the study group (94.23%) was significantly higher than that of the control group (78.85%). Before treatment, there was no significant difference in TG and TC levels between the two groups. After treatment, the levels of TG and TC in both groups were decreased, and the decrease was more obvious in the study group. Compared with before treatment, the levels of 24 h UTP, BUN, Scr, IFN-γ, and TNF-α in both groups were significantly decreased after treatment, while EGFR, IgA, IgG, and IgM levels were significantly increased. Compared with the control group, the changes of each index in the study group were more obvious after treatment. After treatment, the incidence of adverse reactions and recurrence rate in the study group were significantly lower than those in the control group. Conclusions Huaiqihuang granules combined with comprehensive nursing treatment in children with PNS can reduce the occurrence of recent recurrence and adverse reactions and improve the cellular immune function and renal function.
Highlights
Nephrotic syndrome (NS) is a common glomerular disease in children
Combined with the comprehensive nursing methods, the treatment effect can be optimally improved and the immune system of the children can be significantly improved. e results of this study showed that the incidence and recurrence of adverse reactions in the study group were lower than those in the control group, indicating that Huaiqihuang granules combined with comprehensive care can reduce the incidence of respiratory infections and various adverse reactions and further control the recurrence of Primary nephrotic syndrome (PNS)
It has been reported [19, 20] that Huaiqihuang granules can reduce nephrotic proteinuria and relieve nephropathy in children. e results of this study showed that the levels of 24 h UTP, blood urea nitrogen (BUN), and serum creatinine (Scr) in both groups were significantly decreased after treatment, estimated glomerular filtration rate (EGFR) levels were significantly increased
Summary
Nephrotic syndrome (NS) is a common glomerular disease in children. According to reports [1], 21% of children with NS are preschool children, especially at the age of 3–5, and the incidence is generally higher in boys than in girls. e occurrence of NS is related to immune dysfunction, abnormal structure of glomerular capillary wall, and genetic factors. To observe the effect of Huaiqihuang granules combined with comprehensive nursing intervention on children with primary nephrotic syndrome (PNS) and its effect on renal function index. E levels of TG, TC, EGFR, 24 h UTP, BUN, Scr, IgA, IgG, IgM, IFN-c and TNF-α were compared between two groups before and after treatment. E incidence of adverse reactions and recurrence rate after treatment were compared between the two groups. Compared with the control group, the changes of each index in the study group were more obvious after treatment. The incidence of adverse reactions and recurrence rate in the study group were significantly lower than those in the control group. Huaiqihuang granules combined with comprehensive nursing treatment in children with PNS can reduce the occurrence of recent recurrence and adverse reactions and improve the cellular immune function and renal function
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