Abstract
Secretin and cholecystokinin (CCK-PZ) were administered intravenously in graded doses to live anesthetized dogs. Pancreatic secretion and tissue biopsies were analyzed for cyclic AMP content. Both secretin and CCK-PZ caused an output of cyclic AMP into pancreatic secretion, secretin being a more potent stimulant than CCK-PZ. The concentration of cyclic AMP in the pancreatic juice increased with increasing doses of secretin but not with CCK-PZ. Tissue cyclic AMP content remained unchanged during infusion of either secretin or CCK-PZ. Infusion of aminophylline with secretin did not potentiate the action of secretin. It is concluded that synthesis of cyclic AMP in the dog pancreas is stimulated by both secretin and CCK-PZ and that the newly synthesized cyclic AMP is rapidly secreted into pancreatic juice, resulting in a steady content of tissue cyclic AMP.
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