Abstract
Purpose: To evaluate the effects of conjugated hormone replacement therapy (HRT) on dry eye syndrome in postmenopausal women. Methods: Thirty-six healthy postmenopausal women (72 eyes) were included in this three- month prospective study. Schirmer test, tear film break-up time (BUT), fluorescein staining score and symptom score were performed on all patients at the time of enrollment, one month and three months after initiation of HRT. All patients received HRT consisting of conjugated estrogen and progesterone taken orally in a continuous combined regimen. Results: Symptom score significantly decreased from 2.100.79 before HRT to 1.320.84 after one month and to 0.880.67 after three months (p2.54 seconds to 7.992.43 seconds after one month and to 8.932.20 after three months (p0.71 before HRT and decreased to 0.420.60 after one month and to 0.220.42 after three months (p
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