Abstract
The use of hormonal contraceptives has been implicated in the depletion of serum antioxidants and resultant promotion of oxidative stress which is associated with various disorders including cardiovascular disease and cancer. This study investigated serum total antioxidant status (TAS) in women taking hormonal contraceptives and compared their results with non-contraceptive users (age- and sex-matched). Sixty women aged 30 - 45 years, were enrolled for the study which included forty-five users of hormonal contraceptives from the Planned Parenthood Federation of Nigeria, Isolo, Lagos state and fifteen age-matched, apparently healthy, non-contraceptive users from the same geographical location were selected as controls. The in vitro determination of the serum total antioxidant status (TAS) was performed using Biorex enzymatic kit. Data obtained were statistically analyzed using student’s t-test and P < 0.05 was considered significant. The serum levels of TAS in the users of hormonal contraceptives were significantly lower than non-users (P < 0.05). The study concluded that women on hormonal contraceptives especially those taking either combined oral or combined injectable contraceptives were at risk of developing disorders associated with reduced levels of serum antioxidants.
Highlights
Hormonal contraceptives are synthetic biochemical substances that act on the endocrine system and permit sex-How to cite this paper: Adejumo, E.N., Adediji, I.O. and Akinmulero, A.O. (2016) Effect of Hormonal Contraceptives on the Total Antioxidants Status of Women from Isolo, Lagos State, Nigeria
There was a significant decrease in the serum levels of total antioxidant status (TAS) of hormonal contraceptive users when compared with the control subjects
A significant decrease was observed in the serum levels of TAS of oral contraceptive users when compared with the control subjects
Summary
Hormonal contraceptives are synthetic biochemical substances that act on the endocrine system and permit sex-How to cite this paper: Adejumo, E.N., Adediji, I.O. and Akinmulero, A.O. (2016) Effect of Hormonal Contraceptives on the Total Antioxidants Status of Women from Isolo, Lagos State, Nigeria. Hormonal contraceptives are synthetic biochemical substances that act on the endocrine system and permit sex-. How to cite this paper: Adejumo, E.N., Adediji, I.O. and Akinmulero, A.O. (2016) Effect of Hormonal Contraceptives on the Total Antioxidants Status of Women from Isolo, Lagos State, Nigeria. Hormonal contraceptives are used by millions of women worldwide. Other methods of contraception exist, the use of oral and injectable contraceptives is the most popular. In the United States, 18% of women who adopted contraceptive methods to prevent conception relied upon hormonal contraceptives [1]. There are two main classes of hormonal contraceptives and these include combined contraceptives which contain both an oestrogen and a progestin, most oral contraceptives fall under this category and progestogenonly contraceptives which contain only progesterone or a synthetic analogue (progestin)
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