Effect of honey versus intergel in intraperitoneal adhesion prevention and colonic anastomotic healing: A randomized controlled study in rats

Abstract

Introduction Intra-abdominal adhesion formation and reformation after surgery are still an unavoidable event in spite of modern surgical techniques and are a cause of significant morbidity, resulting in infertility, pain and intestinal obstruction. Aim To investigate the effect of honey in adhesion prevention and colonic anastomotic healing in rats. Methods In the present study, 75 male Sprague–Dawley rats were used and divided into 3 groups for study: [25 rats for each], the intergel, honey and control groups. After the scheduled two-week's post-operative period, all survived rats were reopened for second-look laparotomy to detect the following parameters: a – adhesion, b – manometric study, c – histopathological study. Results The author found that the total adhesion score, the manometric values and the histopathological study among the three studied groups showed statistically significant difference and in favor of the honey-treated rats. Conclusion Honey surpasses the intergel for the healing power and adhesion prevention.