Abstract
Background: Skin wounds are a significant public health risk, and treatment of wound remains a challenging clinical problem for medical teams and researchers.Materials and Methods: In the present study, we aimed to investigate the healing effects of honey/polyvinyl alcohol (PVA) hydrogel loaded with erythromycin as wound dressing on skin wounds in rats, based on histological studies. In this study, 60 male Wistar rats, with a 1.5 ×1.5 cm2 diameter full-thickness wounds on the backs were divided into four groups: honey/PVA with the erythromycin hydrogel group, honey group, PVA group, and the control group, with no treatment. Skin biopsies were prepared at days 4, 7, and 14 for microscopic analyses. The stereological analysis, including the mean area of the wound, length of vessels, numerical density of fibroblast, macrophage, basal cell and volume of the epidermis, dermis, and fibrous tissue were performed. Result: Wounds area in the honey/PVA hydrogel with the erythromycin group were significantly (P<0.05) smaller than in the other group. The numerical density of fibroblast, macrophage, basal cell and volume of the epidermis in the honey/PVA hydrogel with the erythromycin group were significantly higher than other groups.Conclusion: According to our results, honey/PVA hydrogel with erythromycin may promote early wound healing and has a positive influence on fibroblast proliferation and re-epithelialization, and its administration is recommended after further validation of clinical data.[GMJ. 2019;8:e1362]
Highlights
The human skin is the largest organs in the body that injured by many harmful external factors, such as an incision, trauma, burns, lacerations, or abrasion [1]
The current study aimed to find the impact of H/polyvinyl alcohol (PVA) hydrogels loaded with erythromycin on the full-thickness skin wound healing process in laboratory rats, and characterized, using stereological analyses to solve the above-mentioned problems for the first time
Our result showed that the number of macrophages in the H/PVA with erythromycin (H/PVA/E) and H/PVA group were significantly lower than other groups
Summary
The human skin is the largest organs in the body that injured by many harmful external factors, such as an incision, trauma, burns, lacerations, or abrasion [1]. Polyvinyl alcohol (PVA) is one of the most clinically effective materials among novel types of wound healing products. The use of hydrogels based on natural saccharides and disaccharides, such as honey and sucrose can increase mechanical strength, biocompatibility, and water uptake of the wound dressing [11, 12]. Materials and Methods: In the present study, we aimed to investigate the healing effects of honey/polyvinyl alcohol (PVA) hydrogel loaded with erythromycin as wound dressing on skin wounds in rats, based on histological studies. The numerical density of fibroblast, macrophage, basal cell and volume of the epidermis in the honey/PVA hydrogel with the erythromycin group were significantly higher than other groups. Conclusion: According to our results, honey/PVA hydrogel with erythromycin may promote early wound healing and has a positive influence on fibroblast proliferation and re-epithelialization, and its administration is recommended after further validation of clinical data. Conclusion: According to our results, honey/PVA hydrogel with erythromycin may promote early wound healing and has a positive influence on fibroblast proliferation and re-epithelialization, and its administration is recommended after further validation of clinical data. [GMJ.2019;8:e1362] DOI:10.31661/gmj.v0i0.1362
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