Abstract
Despite progress in surgical techniques, some patients still face postoperative recurrence of pain. Recently, more attention has been focused on peridural fibrosis (PF), which may be responsible for recurrent pain after laminectomy or discectomy. Honey has been shown to exert anti-inflammatory effects on exposed tissues besides its well-known antibacterial properties. The aim of this study were to investigate the effects of honey on the prevention of postlaminectomy fibrosis formation in a rat model. A controlled blinded study was performed in 45 male adult white Sprague-Dawley rats that underwent laminectomy at the L5-L6 levels. They were divided into 3 groups (A, B, and C) of 15 rats each. Group A (sham) underwent laminectomy and group B was treated with normal saline at the laminectomy site. Rats in group C received 0.1 mL honey at the laminectomy site. All rats were killed 4 weeks after laminectomy. PF was found in 5 rats (33%) of control groups A and B, and in 2 rats (10%) in honey-treated laminectomy group C. The difference was not statistically significant. Wound healing was not affected, and there was no cerebrospinal fluid leakage. Although honey appears to be safe, it cannot cause a significant reduction of PF formation after lumbar laminectomy in rats.
Highlights
Each year, over one million people across the world undergo lumbosacral surgery following disc herniation, making it one of the most common treatments for spinal disorders [1, 2]
More attention has been focused on peridural fibrosis (PF), which may be responsible for recurrent pain after laminectomy or discectomy
In group C, which had received honey, PF was identified in 2 rats with a total score of 7 (Table 7)
Summary
Over one million people across the world undergo lumbosacral surgery following disc herniation, making it one of the most common treatments for spinal disorders [1, 2]. The success rate of repeated surgery for fibrosis is only from 30% to 35%, whereas 15% to 20% of patients report worsening of symptoms [3, 8, 9]. A number of agents have been used to prevent PF, including pharmaceutical gels, gelfoam, or free fat grafts [10]. They are used clinically as the most popular interpositional materials especially after laminectomy [10,11,12], their efficacy is not as impressive as their popularity [13, 14]
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