Abstract
Background: Psoriatic arthritis is a type of arthritis that can often affect some patients who suffer from psoriasis. Approximately 40-50% of individuals with psoriatic arthritis have the HLA-B27 genotype
 Objective: To investigate whether we could confirm the role of HLA-B27 alleles and psoriatic arthritis in Iraqi Arab Muslims patients.
 Method: A cross sectional case control comparative study included thirty Iraqi Arab Muslims who had psoriatic arthritis that consulted the Dermatological and Rheumatological Department in AL-Kindy Teaching Hospital from November 2014 to June 2015. HLA-genotyping for HLA-B27 were assessed. A control group consisted of fifty-one healthy volunteers among the staff of Al-Kindy College of Medicine that did not have psoriatic arthritis or family history of psoriasis. HLA-B*27allele was done by using an Exicycler TM 96 Real-time Quantitative Thermal Block (Bioneer, Daejeon, Korea) and Accupower, HLA-B27 real-time PCR kit (Bioneer, Daejeon , Korea)
 Results: Plaque type psoriasis is more common than other types of psoriasis (66% versus 34%). There is no association between psoriatic arthritis and HLA-B27 with p-value of 0.1197 and Odds ratio (confidence interval) of 2.9375 (0.755-11.415).
 Conclusions: HLA B*27 is not associated with psoriatic arthritis in Iraqi Arab Muslims patients.
Highlights
Psoriatic arthritis is a long – term inflammatory arthritis that occur in people affected by the autoimmune disease psoriasis
The study consisted from Iraqi Arab Muslims patients suspected to have psoriatic arthritis consulted the Dermatological and Rheumatological Department in Al-kindy Teaching Hospital in Baghdad from November 2014 to June 2015
The following 2 detection probes were used: an HLA B27-specific probe and aglyceraldehyde-3-phosphate dihydrogenase (GAPDH) – specific probe, which were labeled with a fluorescent reporter dye FAM (6-carboxy fluorescein) and TAMRA (6-carboxy tetramethyl rhodamine) at the 5 end respectively and a fluorescent quencher dye BHQ (Black hole quencher) at the 3' end, for both
Summary
Psoriatic arthritis is a type of arthritis that can often affect some patients who suffer from psoriasis. 4050% of individuals with psoriatic arthritis have the HLA-B27 genotype Objective: To investigate whether we could confirm the role of HLA-B27 alleles and psoriatic arthritis in Iraqi Arab Muslims patients. Method: A cross sectional case control comparative study included thirty Iraqi Arab Muslims who had psoriatic arthritis that consulted the Dermatological and Rheumatological Department in AL-Kindy Teaching Hospital from November 2014 to June 2015. A control group consisted of fifty-one healthy volunteers among the staff of Al-Kindy College of Medicine that did not have psoriatic arthritis or family history of psoriasis. HLA-B*27allele was done by using an Exicycler TM 96 Real-time Quantitative Thermal Block (Bioneer, Daejeon, Korea) and Accupower, HLA-B27 real-time PCR kit (Bioneer, Daejeon , Korea)
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