Abstract
The effect of histamine on lung cAMP metabolism in normal and Bordetella pertussis-vaccinated mice was investigated. Histamine was shown to elevate lung cAMP in both types of animals in a dose-dependent manner. Pertussis-vaccinated mice, however, showed a marked shift to the left in the histamine dose-response curve. The ED 50 for normal and pertussis-vaccinated mice was 8·0 and 0·25 mg/kg respectively. The histamine-induced rise in cAMP was maximum 1 min after injection and diminished thereafter. The effect of histamine on pulmonary cAMP may be mediated indirectly, as it occurred in vivo but not in vitro.
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