Effect of Hiptage Madablota Gaertn : On High Fat Diet - Induced Obese Rats

Abstract

The present study is designed to evaluate theanti-obesity activity of the roots of Hiptage madablota Gaertn against high fat diet-induced obese rats. In the ethanolic extract of Hiptage madablota (EEHM) total saponin content is also estimated by gravimetric method. Obesity is induced in albino rats by the administration of high fat diet for 40 days. Therefore, this study is accentuated to explore the efficacy of the ethanol extract of Hiptage madablota root at the dose of 100, 200 and 400mg/kg by oral. The anti-obesity activity is estimated in terms of food intake, body weight, lee index, serum lipids, atherogenic index, coronary risk index and brain serotonin level in rats. Preliminary phytoconstituents analysis revealed the presence of flavonoids, terpenoids, saponins, phenolic compounds and tannins. Animal received oral EEHM (100, 200 &400mg/kg) for 40 days, exhibited a significant reduction of food intake, body weight, lee index, serum lipids, atherogenic index, coronary risk index and inversely increased the level of brain serotonin in rats. Thus, the present study indicates that Hiptage madablota root extract possessed significant anti-obese efficacy due to its hypophagic and hypolipidemic effects and provoke the brain serotonin level in rats fed on high fat diet.